{"id":108,"date":"2020-01-22T14:38:00","date_gmt":"2020-01-22T05:38:00","guid":{"rendered":"https:\/\/sarabio.jp\/lab\/?p=108"},"modified":"2025-02-27T13:25:01","modified_gmt":"2025-02-27T04:25:01","slug":"%e3%80%90%e5%8e%9f%e8%91%97%e8%ab%96%e6%96%87%e6%8e%b2%e8%bc%89%e3%80%91%e3%83%95%e3%82%a1%e3%83%bc%e3%83%9e%e3%82%b3%e3%83%ad%e3%82%b8%e3%82%ab%e3%83%ab%e3%83%bb%e3%83%aa%e3%82%b5%e3%83%bc%e3%83%81p","status":"publish","type":"post","link":"https:\/\/sarabio.jp\/lab\/index.php\/achievement\/paper\/108\/","title":{"rendered":"\u3010\u539f\u8457\u8ad6\u6587\u63b2\u8f09\u3011\u30d5\u30a1\u30fc\u30de\u30b3\u30ed\u30b8\u30ab\u30eb\u30fb\u30ea\u30b5\u30fc\u30c1(Pharmacological Research)"},"content":{"rendered":"\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full\"><img width=\"900\" height=\"400\" src=\"https:\/\/sarabio.jp\/lab\/wp-content\/uploads\/2023\/08\/pharma2020012201.png\" alt=\"\" class=\"wp-image-109\"\/><\/figure><\/div>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>  \u85ac\u5b66\u7814\u7a76\u5206\u91ce\u306e\u67fb\u8aad\u4ed8\u304d\u5c02\u9580\u8a8c\u300c\u30d5\u30a1\u30fc\u30de\u30b3\u30ed\u30b8\u30ab\u30eb\u30fb\u30ea\u30b5\u30fc\u30c1(Pharmacological Research)\u300d\u306b\u3066\u3001\u751f\u6d3b\u7fd2\u6163\u75c5\u306b\u304a\u3051\u308b\u201d\u6e29\u6cc9\u85fb\u985eRG92\u201d\u306e\u4f5c\u7528\u306b\u95a2\u3059\u308b\u539f\u8457\u8ad6\u6587\u304c\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<br> \u751f\u6d3b\u7fd2\u6163\u75c5\u5bfe\u7b56\u306b\u304a\u3044\u3066RG92\u304c\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u6539\u5584\u306b\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u3092\u793a\u3057\u9ad8\u3044\u8a55\u4fa1\u3092\u5f97\u307e\u3057\u305f\u3002  <\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2>  \u300c\u30d5\u30a1\u30fc\u30de\u30b3\u30ed\u30b8\u30ab\u30eb\u30fb\u30ea\u30b5\u30fc\u30c1\u300d\u306b\u3064\u3044\u3066  <\/h2>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>  \u300c\u30d5\u30a1\u30fc\u30de\u30b3\u30ed\u30b8\u30ab\u30eb\u30fb\u30ea\u30b5\u30fc\u30c1(Pharmacological Research)\u300d\u306f\u3001\u30aa\u30e9\u30f3\u30c0\u306eELSEVIER(\u30a8\u30eb\u30bc\u30d3\u30a2)\u793e\u304c\u767a\u884c\u3059\u308b\u85ac\u5b66\u7814\u7a76\u306e\u5206\u91ce\u306b\u304a\u3051\u308b\u5c02\u9580\u8a8c\u3067\u3059\u3002<br> \u5b66\u8853\u8a8c\u306e\u30a4\u30f3\u30d1\u30af\u30c8\u30d5\u30a1\u30af\u30bf\u30fc\u306f5.57\u3001\u63b2\u8f09\u306b\u306f\u67fb\u8aad\u3068\u547c\u3070\u308c\u308b<strong>\u540c\u5206\u91ce\u7814\u7a76\u8005\u306b\u3088\u308b\u5be9\u67fb<\/strong>\u304c\u5fc5\u9808\u3068\u306a\u308a\u307e\u3059\u3002<br> \u3053\u306e\u3088\u3046\u306a\u300c\u67fb\u8aad\u4ed8\u304d\u5c02\u9580\u8a8c\u300d\u306b\u63b2\u8f09\u3055\u308c\u308b\u3068\u3044\u3046\u3053\u3068\u306f\u3001\u63b2\u8f09\u8ad6\u6587\u304c<strong>\u540c\u5206\u91ce\u306e\u7814\u7a76\u8005\u304b\u3089\u9ad8\u3044\u8a55\u4fa1\u3092\u5f97\u3066\u3044\u308b\u8a3c<\/strong>\u3067\u3042\u308a\u3001\u4fe1\u983c\u6027\u306e\u73fe\u308c\u3067\u3082\u3042\u308a\u307e\u3059\u3002  <\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3> \u80cc\u666f <\/h3>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u30b5\u30e9\u30f4\u30a3\u30aa\u5316\u7ca7\u54c1\u306f\u3001<span class=\"f_red\">\u5e73\u621027\u5e74\u5ea6\u6226\u7565\u7684\u57fa\u76e4\u6280\u8853\u9ad8\u5ea6\u5316\u652f\u63f4\u4e8b\u696d\u3068\u3057\u3066\u63a1\u629e<\/span>\u3055\u308c\u3001\u65e5\u672c\u521d\u306e\u7cd6\u5c3f\u75c5\u4e88\u9632\u85ac\u30fb\u6cbb\u7642\u85ac\u958b\u767a\u306b\u5411\u3051\u305f\u57fa\u790e\u7814\u7a76\u3092\u3001\u7cd6\u5c3f\u75c5\u7814\u7a76\u306e\u7b2c\u4e00\u4eba\u8005\u3067\u3082\u3042\u308b\u4e45\u7559\u7c73\u5927\u5b66\u533b\u5b66\u90e8\u30fb\u5c71\u5cb8\u660c\u4e00\u6559\u6388\u306e\u7814\u7a76\u30c1\u30fc\u30e0\u3068\u5171\u540c\u3067\u884c\u3063\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u5171\u540c\u7814\u7a76\u3092\u9032\u3081\u308b\u4e2d\u3001\u751f\u6d3b\u7fd2\u6163\u75c5\u306b\u95a2\u4fc2\u3059\u308b\u6570\u5024\u306b\u5bfe\u3057\u6e29\u6cc9\u85fb\u985eRG92\u304c\u3069\u306e\u3088\u3046\u306a\u4f5c\u7528\u3092\u3082\u305f\u3089\u3059\u304b\u691c\u8a3c\u3092\u884c\u3044\u3001\u305d\u306e\u7814\u7a76\u5185\u5bb9\u306b\u95a2\u3059\u308b\u8ad6\u6587\u304c\u85ac\u5b66\u5c02\u9580\u8a8c\u300cPharmacological Research\u300d\u306b\u3066\u53d7\u7406\u3055\u308c\u63b2\u8f09\u30fb\u30aa\u30f3\u30e9\u30a4\u30f3\u306b\u3066\u516c\u958b\u9802\u3051\u308b\u3053\u3068\u3068\u306a\u308a\u307e\u3057\u305f\u3002<br> \u3053\u306e\u5c71\u5cb8\u6559\u6388\u3068\u306e\u5171\u540c\u7814\u7a76\u306e\u6210\u679c\u306f\u3001\u30b5\u30e9\u30f4\u30a3\u30aa\u5316\u7ca7\u54c1\u304c\u7d4c\u6e08\u7523\u696d\u7701\u304b\u3089\u8a8d\u5b9a\u3092\u53d7\u3051\u305f\u30b5\u30dd\u30a4\u30f3\u4e8b\u696d\u306b\u304a\u3051\u308b\u6210\u679c\u306e\u4e00\u3064\u3067\u3082\u3042\u308a\u3001\u307e\u305f\u3001\u3053\u308c\u304b\u3089\u306e\u7814\u7a76\u306e\u767a\u5c55\u306b\u5411\u3051\u3066\u5927\u304d\u304f\u7e4b\u304c\u308b\u3053\u3068\u3068\u8a00\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2> \u8ad6\u6587\u63b2\u8f09\u5185\u5bb9 <\/h2>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3>  \u6982\u8981  <\/h3>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p> \u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u4f5c\u7528\u304c\u920d\u5316\u3059\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306f\u3001\u80a5\u6e80\u306b\u4f34\u3063\u3066\u9032\u884c\u3059\u308b\u8102\u80aa\u7d44\u7e54\u306b\u304a\u3051\u308b\u708e\u75c7\u53cd\u5fdc\u306b\u3088\u308a\u60f9\u8d77\u3055\u308c\u308b\u3002<br> 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vitro\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u6297\u708e\u75c7\u4f5c\u7528\u3092\u6709\u3059\u308b\u3053\u3068\u3001\uff12\uff09<span class=\"f_red\">\u8102\u80aa\u7d30\u80de\u306e\u708e\u75c7\u3084\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u53cd\u5fdc\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3002<\/span><br>\n\u305d\u3053\u3067\u3001\u4eca\u56de\u3001\u30d2\u30c8\u306b\u304a\u3044\u3066\u3082\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u304c\u6539\u5584\u3055\u308c\u308b\u304b\u3069\u3046\u304b\u691c\u8a3c\u3059\u308b\u305f\u3081\u306b\u3001\u904e\u4f53\u91cd\uff08\u80a5\u6e80\u6c17\u5473\uff09\u306e\u88ab\u9a13\u8005\u3092\u52df\u3063\u3066\u30d2\u30c8\u4ecb\u5728\u8a66\u9a13\u3092\u5b9f\u65bd\u3057\u305f\u3002<\/p>\n\n\n\n<p> BMI25\u4ee5\u4e0a30\u672a\u6e80\u306e20\u6b73\u304b\u308964\u6b73\u306e\u7537\u597330\u540d\u3092\u540415\u540d\u305a\u3064\u306b\u30e9\u30f3\u30c0\u30e0\u306b\u5206\u3051\u3001\u5404\u3005\u306e\u88ab\u9a13\u8005\u306b\u6e29\u6cc9\u85fb\u985eRG92\u914d\u5408\uff080.1g\uff09\u3001\u53c8\u306f\u30d7\u30e9\u30bb\u30dc\u306e\u30ab\u30d7\u30bb\u30eb\u3092\u30011\u65e55\u30ab\u30d7\u30bb\u30eb\u300112\u9031\u9593\u9023\u65e5\u3067\u6442\u53d6\u3057\u3066\u3082\u3089\u3063\u305f\u3002\u6442\u53d6\u5f8c\u30014\u9031\u30018\u9031\u300112\u9031\u306b\u8eab\u4f53\u6e2c\u5b9a\u3001\u8840\u6db2\u691c\u67fb\u3001\u533b\u5e2b\u306b\u3088\u308b\u6240\u898b\u8a55\u4fa1\u3092\u884c\u3063\u305f\u3002<br> \u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u8f9e\u9000\u80051\u540d\u304c\u51fa\u305f\u70ba\u3001\u8a66\u9a13\u7d42\u4e86\u6642\u306f\u6e29\u6cc9\u85fb\u985e\u7fa4\u306f15\u540d\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u306f14\u540d\u3067\u3042\u3063\u305f\u3002 <\/p>\n\n\n\n<p> \u6e29\u6cc9\u85fb\u985eRG92\u7c89\u672b\u306e12\u9031\u9593\u6442\u53d6\u306b\u3088\u308a\u3001\u7a7a\u8179\u6642\u8840\u7cd6\u5024\u304a\u3088\u3073\u8840\u6e05\u30a4\u30f3\u30b9\u30ea\u30f3\u5024\u306b\u6539\u5584\u304c\u8a8d\u3081\u3089\u308c\u3001\u305d\u308c\u306b\u4f34\u3063\u3066\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\uff08\u6307\u6a19\u5024\u3068\u3057\u3066HOMA-R\uff09\u3082\u7d4c\u6642\u7684\u306b\u6539\u5584\u3055\u308c\u305f\u3002\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u306e\u6bd4\u8f03\u306b\u304a\u3044\u3066\u3082\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306f\u6709\u610f\u306b\u4f4e\u3044\u5024\u3092\u793a\u3057\u305f\u3002<br> \u8179\u56f2\u9577\u306f\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u5e73\u57470.55cm\u5897\u52a0\u3057\u305f\u306e\u306b\u5bfe\u3057\u3066\u3001\u6e29\u6cc9\u85fb\u985e\u6442\u53d6\u7fa4\u3067\u306f90.5cm\u304b\u308989.0cm\u306b\u6e1b\u5c11\u3059\u308b\u50be\u5411\u304c\u8a8d\u3081\u3089\u308c\u3001\u6442\u53d6\u5f8c12\u9031\u9593\u306b\u304a\u3044\u3066\u306f\u7fa4\u9593\u50be\u5411\u5dee\u304c\u5f97\u3089\u308c\u305f\u3002<br> \u305d\u306e\u4ed6\u3001\u62e1\u5f35\u671f\u8840\u5727\u3001\u8108\u62cd\u6570\u306b\u304a\u3044\u3066\u3082\u3001\u6e29\u6cc9\u85fb\u985eRG92\u6442\u53d6\u306b\u3088\u308b\u6539\u5584\u52b9\u679c\u304c\u8a8d\u3081\u3089\u308c\u305f\u3002\u8a66\u9a13\u671f\u9593\u3092\u901a\u3058\u3066\u91cd\u7be4\u306a\u6709\u5bb3\u4e8b\u8c61\u306f\u307f\u3089\u308c\u305a\u3001\u88ab\u9a13\u54c1\u306b\u8d77\u56e0\u3059\u308b\u6709\u5bb3\u4e8b\u8c61\u306e\u5831\u544a\u3082\u306a\u304b\u3063\u305f\u3002 <\/p>\n\n\n\n<p>\u5f93\u3063\u3066\u3001\u6e29\u6cc9\u85fb\u985eRG92\u306e\u6442\u53d6\u306f\u80a5\u6e80\u6c17\u5473\u306e\u88ab\u9a13\u8005\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u751f\u6d3b\u7fd2\u6163\u75c5\u306b\u95a2\u3059\u308b\u4e3b\u8981\u9805\u76ee\u3092\u6539\u5584\u3057\u3001\u8179\u56f2\u9577\u306e\u6e1b\u5c11\u306b\u5bc4\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u305f\u3002<br>\n\u5b89\u5168\u6027\u306b\u304a\u3051\u308b\u554f\u984c\u3082\u307f\u3089\u308c\u306a\u304b\u3063\u305f\u3053\u3068\u304b\u3089\u3001<span class=\"f_red\">\u6e29\u6cc9\u85fb\u985eRG92\u306f\u3001\u80a5\u6e80\u6c17\u5473\u306e\u30d2\u30c8\u3067\u306e\u7cd6\u5c3f\u75c5\u4e88\u9632\u3084\u80a5\u6e80\u4e88\u9632\u306b\u6709\u7528\u3067\u3042\u308b<\/span>\u3068\u8003\u3048\u3089\u308c\u305f\u3002<\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3>  \u5e8f\u8ad6  <\/h3>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u5225\u5e9c\u6e29\u6cc9\u3067\u767a\u898b\u3057\u305f\u5fae\u7d30\u85fb\u985e(Mucidosphaerium sp., \u4ee5\u5f8c\u6e29\u6cc9\u85fb\u985eRG92)\u306f\u3001\u30d2\u30c8\u306e\u76ae\u819a\u3001\u982d\u76ae\u3001\u307e\u305f\u306f\u95a2\u7bc0\u7531\u6765\u306e\u7d30\u80de\u3092\u7528\u3044\u305f\u7d30\u80de\u751f\u7269\u5b66\u7684\u89e3\u6790\u306b\u304a\u3044\u3066\u3001\u6297\u708e\u75c7\u4f5c\u7528\u3001\u6297\u9178\u5316\u4f5c\u7528\u3001\u3055\u3089\u306b\u7d42\u672b\u7cd6\u5316\u7523\u7269(AGEs)\u306b\u3088\u308b\u7d30\u80de\u30c0\u30e1\u30fc\u30b8\u3092\u7de9\u548c\u3059\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u305f\uff08Alternative Therapies in Health and Medicine, in press\uff09\u3002<br> \u30d2\u30c8\u95a2\u7bc0\u7531\u6765\u306e\u6ed1\u819c\u7d30\u80de\u3092\u7528\u3044\u305f\u7cfb\u306b\u304a\u3044\u3066\u306f\u3001IL-1\u03b2\u523a\u6fc0\u306b\u3088\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5f62\u614b\u304a\u3088\u3073\u6a5f\u80fd\u306e\u969c\u5bb3\u3092\u7de9\u548c\u3059\u308b\u4f5c\u7528\u3082\u8a8d\u3081\u3089\u308c\u305f\uff08Molecular Medicine: Current Aspects (2017) Volume 1, Issue 1, 003\uff09\u3002<br> \u3053\u308c\u3089\u306e\u7d30\u80de\u751f\u7269\u5b66\u7684\u89e3\u6790\u306e\u6240\u898b\u306fRG92\u306e\u62bd\u51fa\u7269\u3092\u4f7f\u3063\u3066\u958b\u767a\u3057\u305f\u5546\u54c1\u7fa4\u306e\u7279\u6027\uff08\u76ae\u819a\u306e\u6539\u5584\u3001\u75db\u307f\u306e\u6539\u5584\u306a\u3069\uff09\u3068\u4e00\u81f4\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<p>\u751f\u6d3b\u7fd2\u6163\u75c5\u3092\u907f\u3051\u308b\u70ba\u306b\u306f\u3001\u4e88\u9632\u306b\u52aa\u3081\u305f\u308a\u672a\u75c5\u306b\u3042\u308b\u72b6\u614b\u3092\u3044\u3061\u65e9\u304f\u8131\u3059\u308b\u3053\u3068\u304c\u671b\u307e\u308c\u308b\u3002 \u6e29\u6cc9\u85fb\u985eRG92\u306f\u7d4c\u76ae\u5438\u53ce\u3060\u3051\u3067\u306a\u304f\u7d4c\u53e3\u6442\u53d6\u3057\u305f\u5834\u5408\u306b\u3082\u5404\u81d3\u5668\u306b\u304a\u3051\u308b\u6539\u5584\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u308b\u3002\u305d\u3053\u3067\u3001\u98df\u54c1\u7528\u306e\u30d1\u30a6\u30c0\u30fc\u539f\u6599\u3092\u958b\u767a\u3057\u3001\u4e00\u9023\u306e\u6bd2\u6027\u8a66\u9a13\u3092\u5b9f\u65bd\u3057\u5b89\u5168\u6027\u3092\u78ba\u304b\u3081\u305f\u4e0a\u3067in vivo \u8a66\u9a13\u3092\u884c\u3063\u305f\u3002<br>\n\u4f53\u91cd\u3001\u8840\u5727\u3001\u8840\u7cd6\u5024\u3001\u8840\u4e2d\u8102\u8cea\u306e\u5909\u5316\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u304c\u3001\u8840\u6e05\u30a4\u30f3\u30b9\u30ea\u30f3\u5024\u304a\u3088\u3073\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\uff08HOMA-R\uff09\u306f\u6709\u610f\u306b\u5897\u52a0\u3057\u305f\u3002\u305d\u308c\u306b\u5bfe\u3057\u3066\u3001\u6e29\u6cc9\u85fb\u985eRG92\u3092\u540c\u6642\u6442\u53d6\u3057\u305f\u5834\u5408\u306b\u306f\u3001\u3053\u308c\u3089\u306e\u6570\u5024\u306e\u5897\u52a0\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3002<br>\n<span class=\"f_red\">\u3053\u306e\u7d50\u679c\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u5024\u304c\u9ad8\u3044\u72b6\u614b\u304c\u7d9a\u304f\u3068\u751f\u6d3b\u7fd2\u6163\u75c5\u306b\u306a\u308b\u3067\u3042\u308d\u3046\u672a\u75c5\u72b6\u614b\u3092\u6539\u5584\u3057\u305f\u3053\u3068\u3092\u793a\u5506\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002<\/span><\/p>\n\n\n\n<p>\u6e29\u6cc9\u85fb\u985eRG92\u306e\u4f5c\u7528\u6a5f\u69cb\u3092\u8abf\u3079\u308b\u305f\u3081\u306b\u8102\u80aa\u7d44\u7e54\u3092\u89e3\u6790\u3057\u305f\u7d50\u679c\u3001\u5f53\u7c89\u672b\u3092\u540c\u6642\u6442\u53d6\u3057\u305f\u5834\u5408\u306b\u306f\u3001\u9ad8\u30d5\u30eb\u30af\u30c8\u30fc\u30b9\u6442\u53d6\u304c\u5f15\u304d\u8d77\u3053\u3059AGEs\u306e\u904e\u5270\u84c4\u7a4d\u3001RAGE\u306e\u904e\u5270\u767a\u73fe\u3001\u708e\u75c7\u6027\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e\u6d78\u6f64\u3001\u8102\u80aa\u7d30\u80de\u306e\u80a5\u5927\u5316\u304c\u6291\u5236\u3055\u308c\u305f\u3002<br>\n\u66f4\u306b\u3001\u3053\u308c\u3089\u306e\u4f5c\u7528\u306b\u306f\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u6291\u5236\u3001MCP-1\u904e\u5270\u767a\u73fe\u306e\u6291\u5236\u3084\u30a2\u30c7\u30a3\u30dd\u30cd\u30af\u30c1\u30f3\u306e\u767a\u73fe\u306e\u56de\u5fa9\u304c\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002 \u57f9\u990a\u8102\u80aa\u7d30\u80de\uff083T3-L1\uff09\u3092\u7528\u3044\u305f\u5b9f\u9a13\u7cfb\u306b\u304a\u3044\u3066\u3082\u3001\u6e29\u6cc9\u85fb\u985eRG92\u306fAGE\u523a\u6fc0\u306b\u4f34\u3046\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3001RAGE\u907a\u4f1d\u5b50\u306e\u904e\u5270\u767a\u73fe\u3001\u8102\u80aa\u6ef4\u306e\u904e\u5270\u84c4\u7a4d\u3001MCP-1\u907a\u4f1d\u5b50\u306e\u904e\u5270\u767a\u73fe\u3092\u6291\u5236\u3057\u3001\u30a2\u30c7\u30a3\u30dd\u30cd\u30af\u30c1\u30f3\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u6709\u610f\u306b\u5897\u52a0\u3057\u305f\u3002 RG92\u7c89\u672b\u304b\u3089\u8abf\u88fd\u3057\u305f\u7c97\u7cd6\u8102\u8cea\u753b\u5206\uff08DGDG\u3092\u542b\u3080\uff09\u3001\u304a\u3088\u3073\u3001DGDG\u6a19\u6e96\u54c1\u306fAGE\u304c\u5f15\u304d\u8d77\u3053\u3059\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3068\u8102\u80aa\u6ef4\u306e\u904e\u5270\u84c4\u7a4d\u3092\u6291\u5236\u3059\u308b\u52b9\u679c\u3092\u793a\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u7dcf\u3058\u3066\u3001\uff11\uff09\u6e29\u6cc9\u85fb\u985eRG92\u306fAGE-RAGE\u7cfb\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3001\u708e\u75c7\u53cd\u5fdc\u306e\u6291\u5236\u3092\u4ecb\u3057\u3066\u8102\u80aa\u7d44\u7e54\u306e\u80a5\u5927\u5316\u304a\u3088\u3073\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u3001\uff12\uff09\u6e29\u6cc9\u85fb\u985eRG92\u306b\u542b\u307e\u308c\u308bDGDG\u304c\u305d\u308c\u3089\u306e\u4f5c\u7528\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u305f\u3002<\/p>\n\n\n\n<p>\u6e29\u6cc9\u85fb\u985eRG92\u306f\u30d2\u30c8\u306b\u304a\u3044\u3066\u3082\u540c\u69d8\u306b\u751f\u6d3b\u7fd2\u6163\u75c5\u306b\u3064\u306a\u304c\u308b\u672a\u75c5\u72b6\u614b\u3092\u6539\u5584\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u305d\u3053\u3067\u3001\u304a\u8179\u5468\u308a\u304c\u6c17\u306b\u306a\u308b\u88ab\u9a13\u8005\uff08BMI 25-30\uff09\u5bfe\u3059\u308b\u30d2\u30c8\u4ecb\u5728\u8a66\u9a13\u3092\u5b9f\u65bd\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3> \u65b9\u6cd5 <\/h3>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p> \u30d8\u30eb\u30b7\u30f3\u30ad\u5ba3\u8a00\u306b\u6e96\u62e0\u3057\u502b\u7406\u59d4\u54e1\u4f1a\u3067\u627f\u8a8d\u3092\u5f97\u305f\u8a08\u753b\u66f8\u306b\u57fa\u3065\u304d2\u91cd\u76f2\u691c\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u30e9\u30f3\u30c0\u30e0\u5316\u4e26\u884c\u7fa4\u9593\u6bd4\u8f03\u8a66\u9a13\u3092\u5b9f\u65bd\u3057\u305f\uff08\u682a\u5f0f\u4f1a\u793eSOUKEN\u306b\u3088\u308b\u5916\u6ce8\u8a66\u9a13\uff09\u3002<br> 20\uff5e64\u6b73\u3067BMI\u304c25\u4ee5\u4e0a30\u672a\u6e80\u304b\u3064HbA1c\u304c6.5%\u672a\u6e80\u3092\u6e80\u305f\u3059\u5065\u5e38\u6210\u4eba\u304b\u3089\u88ab\u9a13\u800530\u540d\u3092\u9078\u629c\u3057\u3001\u7121\u4f5c\u70ba\u306b\u30d7\u30e9\u30bb\u30dc\u7fa4\uff08n=15\u3001\u3046\u30611\u540d\u304c\u9014\u4e2d\u8131\u843d\uff09\u3068\u6e29\u6cc9\u85fb\u985eRG92\u7fa4\uff08n=15\uff09\u306b\u5206\u3051\u305f\u3002<br> \u5404\u7fa4\u306b\u30d7\u30e9\u30bb\u30dc\u30ab\u30d7\u30bb\u30eb\u3001\u3082\u3057\u304f\u306f\u3001\u6e29\u6cc9\u85fb\u985eRG92 (0.1g)\u542b\u6709\u30ab\u30d7\u30bb\u30eb\u30925\u9320\/\u65e5\u306712\u9031\u9593\u9023\u65e5\u6442\u53d6\u3055\u305b\u3001\u7d99\u6642\u7684\u306b\u8eab\u4f53\u6e2c\u5b9a\u3001\u8840\u6db2\u691c\u67fb\u3001\u8840\u5727\u30fb\u8108\u62cd\u6e2c\u5b9a\u3001\u533b\u5e2b\u306b\u3088\u308b\u6240\u898b\u8a55\u4fa1\u3092\u884c\u3063\u305f\u3002<br> \u7d71\u8a08\u51e6\u7406\u306f\u3001paired t test\u3001\u307e\u305f\u306f\u3001Dunnett\u306e\u691c\u5b9a\uff08\u6709\u610f\u6c34\u6e96\uff1a\u4e21\u5074\u691c\u5b9a\u3001\u5371\u967a\u73875%\uff09\u3092\u7528\u3044\u305f\u3002 <\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3> \u7d50\u679c <\/h3>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>20\u6b73\u304b\u308964\u6b73\u306e\u7537\u5973\uff08\u6e29\u6cc9\u85fb\u985eRG92\u7fa4\uff1a\u7537\u60277\u540d\u5973\u60278\u540d\u3001\u5e73\u5747\u5e74\u9f6245.7\u00b19.6\u6b73\u3001BMI 27.1\u00b11.3\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\uff1a\u7537\u60278\u540d\u3001\u5973\u60276\u540d\u3001\u5e73\u5747\u5e74\u9f6246.1\u00b110.6\u6b73\u3001BMI 27.1\u00b11.3 \uff09\u3067\u8a66\u9a13\u3092\u5b9f\u65bd\u3001\u5b8c\u4e86\u3057\u305f\u3002<br> \u91cd\u7be4\u306a\u6709\u5bb3\u4e8b\u8c61\u306f\u307f\u3089\u308c\u305a\u3001\u88ab\u9a13\u54c1\u306b\u8d77\u56e0\u3059\u308b\u6709\u5bb3\u4e8b\u8c61\u306f\u307f\u3089\u308c\u306a\u304b\u3063\u305f\u3002<br> \u7a7a\u8179\u6642\u8840\u7cd6\u5024\u304c\u6e29\u6cc9\u85fb\u985eRG92\u306e\u6442\u53d6\u5f8c12\u9031\u306b\u8457\u3057\u304f\u6e1b\u5c11\u3057\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u306e\u7fa4\u9593\u6bd4\u8f03\u306b\u304a\u3044\u3066\u6709\u610f\u306a\u4f4e\u5024\u3092\u793a\u3057\u305f<span class=\"f_70\">\uff08\u56f3\uff11\uff09<\/span>\u3002<br> \u62e1\u5f35\u671f\u8840\u5727\u3082\u8a66\u9a13\u958b\u59cb\u5f8c\u306b\u5897\u52a0\u50be\u5411\u3092\u793a\u3059\u30d7\u30e9\u30bb\u30dc\u7fa4\u306b\u5bfe\u3057\u3066\u3001\u6e29\u6cc9\u85fb\u985e\u6442\u53d6\u7fa4\u3067\u306f\u7d4c\u6642\u7684\u306a\u6e1b\u5c11\u3092\u793a\u3057\u3001\u6709\u610f\u306b\u4f4e\u5024\u3092\u793a\u3057\u305f<span class=\"f_70\">\uff08\u56f3\uff12\uff09<\/span>\u3002<br> \u8840\u4e2d\u30a4\u30f3\u30b9\u30ea\u30f3\u5024\u3082\u540c\u69d8\u306e\u7d4c\u6642\u5909\u5316\u3092\u793a\u3057\u305f<span class=\"f_70\">\uff08\u56f3\uff13\uff09<\/span>\u3002<br> \u8840\u7cd6\u5024\u3068\u30a4\u30f3\u30b9\u30ea\u30f3\u5024\u304b\u3089\u7b97\u51fa\u3057\u305f\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u6307\u6570\uff08HOMA-R)\u3082\u540c\u69d8\u306e\u7d4c\u6642\u7684\u306a\u6e1b\u5c11\u50be\u5411\u3092\u793a\u3057\u3001\u8a66\u9a13\u958b\u59cb\u5f8c4\u9031\u30018\u9031\u300112\u9031\u3067\u6709\u610f\u306a\u7fa4\u9593\u5dee\u3092\u793a\u3057\u305f<span class=\"f_70\">\uff08\u56f3\uff14\uff09<\/span>\u3002\u540c\u69d8\u306b\u3001\u8108\u62cd\u6570\u3082\u6e29\u6cc9\u85fb\u985e\u6442\u53d6\u5f8c12\u9031\u306b\u6709\u610f\u3068\u306a\u308b\u7d4c\u6642\u7684\u306a\u6e1b\u5c11\u3092\u793a\u3057\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u306e\u6bd4\u8f03\u306b\u304a\u3044\u3066\u3082\u6709\u610f\u306b\u4f4e\u3044\u5024\u3092\u793a\u3057\u305f<span class=\"f_70\">\uff08\u8868\uff11\uff09<\/span>\u3002<br> \u6e29\u6cc9\u85fb\u985eRG92\u7fa4\u3067\u4f53\u91cd\u304c\u5e73\u57470.45kg\u5897\u52a0\u3057\u3066\u3044\u308b\u306e\u306b\u95a2\u308f\u3089\u305a\u3001\u8179\u56f2\u9577\u306f90.5\u00b17.7cm\u304b\u308989.0\u00b17.7cm\u3068\u7d71\u8a08\u7684\u306a\u6709\u610f\u5dee\u306f\u8a8d\u3081\u3089\u308c\u306a\u3044\u3082\u306e\u306e\u7d4c\u6642\u7684\u306a\u6e1b\u5c11\u50be\u5411\u3092\u793a\u3057\u305f<span class=\"f_70\">\uff08\u56f3\uff15\uff09<\/span>\u3002\u8179\u56f2\u9577\u304c\u5e73\u57470.55cm\u5897\u52a0\u3057\u305f\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u3068\u306f\u5bfe\u7167\u7684\u3067\u3042\u308a\u3001\u8a66\u9a13\u958b\u59cb12\u9031\u9593\u5f8c\u306e\u8179\u56f2\u9577\u3067\u306f\u7fa4\u9593\u50be\u5411\u5dee\u304c\u307f\u3089\u308c\u305f(p=0.099)\u3002<\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full\"><img width=\"2250\" height=\"926\" src=\"https:\/\/sarabio.jp\/lab\/wp-content\/uploads\/2023\/08\/pharma2020012202.png\" alt=\"\" class=\"wp-image-110\"\/><\/figure><\/div>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full\"><img width=\"2250\" height=\"915\" src=\"https:\/\/sarabio.jp\/lab\/wp-content\/uploads\/2023\/08\/pharma2020012203.png\" alt=\"\" class=\"wp-image-111\"\/><\/figure><\/div>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full\"><img width=\"1024\" height=\"475\" src=\"https:\/\/sarabio.jp\/lab\/wp-content\/uploads\/2023\/08\/pharma2020012204.png\" alt=\"\" class=\"wp-image-112\"\/><\/figure><\/div>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full\"><img width=\"1024\" height=\"551\" src=\"https:\/\/sarabio.jp\/lab\/wp-content\/uploads\/2023\/08\/pharma2020012205.png\" alt=\"\" class=\"wp-image-113\"\/><\/figure><\/div>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3> \u307e\u3068\u3081 <\/h3>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u4e8c\u91cd\u76f2\u691c\u30d2\u30c8\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u6e29\u6cc9\u85fb\u985eRG92\u3092\u9023\u7d9a\u6442\u53d6\uff080.5g\u300112\u9031\u9593\uff09\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001<strong>\u8840\u7cd6\u5024\u3001\u8840\u5727\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5024\u3001\u8108\u62cd\u6570\u306e\u7d4c\u6642\u7684\u306a\u6539\u5584<\/strong>\u304c\u8a8d\u3081\u3089\u308c\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u306e\u6bd4\u8f03\u306b\u304a\u3044\u3066\u3082\u6709\u610f\u306b<strong>\u4f4e\u3044\u5024<\/strong>\u3092\u793a\u3057\u305f\u3002<br><strong>\u8179\u56f2\u9577\u3082\u6e1b\u5c11<\/strong>\u3059\u308b\u50be\u5411\u304c\u307f\u3089\u308c\u3001\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\u306e\u4e88\u9632\u3001\u6539\u5584\u306b\u6709\u7528\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002<br>\u80a5\u6e80\u3001\u9ad8\u8840\u5727\u3001\u9ad8\u8102\u8840\u75c7\u3001\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u30fb\u91cd\u75c7\u5316\u306e\u30d0\u30ed\u30e1\u30fc\u30bf\u30fc\u3068\u306a\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u304c\u6539\u5584\u3055\u308c\u305f\u3053\u3068\u306f\u3001\u6c17\u3065\u304b\u306a\u3044\u5185\u306b\u9032\u884c\u3057\u3066\u3044\u308b\u304b\u3082\u3057\u308c\u306a\u3044<strong>\u751f\u6d3b\u7fd2\u6163\u75c5\u306e\u4e88\u9632\u3084\u6539\u5584\u306b\u6709\u7528\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u5506<\/strong>\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full\"><img width=\"778\" height=\"1039\" src=\"https:\/\/sarabio.jp\/lab\/wp-content\/uploads\/2020\/01\/pharmacological-research_top.png\" alt=\"\" class=\"wp-image-584\"\/><\/figure><\/div>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u85ac\u5b66\u7814\u7a76\u5206\u91ce\u306e\u67fb\u8aad\u4ed8\u304d\u5c02\u9580\u8a8c\u300c\u30d5\u30a1\u30fc\u30de\u30b3\u30ed\u30b8\u30ab\u30eb\u30fb\u30ea\u30b5\u30fc\u30c1(Pharmacological Research)\u300d\u306b\u3066\u3001\u751f\u6d3b\u7fd2\u6163\u75c5\u306b\u304a\u3051\u308b\u201d\u6e29\u6cc9\u85fb\u985eRG92\u201d\u306e\u4f5c\u7528\u306b\u95a2\u3059\u308b\u539f\u8457\u8ad6\u6587\u304c\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002 \u751f [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":114,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[4],"tags":[],"_links":{"self":[{"href":"https:\/\/sarabio.jp\/lab\/index.php\/wp-json\/wp\/v2\/posts\/108"}],"collection":[{"href":"https:\/\/sarabio.jp\/lab\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sarabio.jp\/lab\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sarabio.jp\/lab\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/sarabio.jp\/lab\/index.php\/wp-json\/wp\/v2\/comments?post=108"}],"version-history":[{"count":5,"href":"https:\/\/sarabio.jp\/lab\/index.php\/wp-json\/wp\/v2\/posts\/108\/revisions"}],"predecessor-version":[{"id":586,"href":"https:\/\/sarabio.jp\/lab\/index.php\/wp-json\/wp\/v2\/posts\/108\/revisions\/586"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sarabio.jp\/lab\/index.php\/wp-json\/wp\/v2\/media\/114"}],"wp:attachment":[{"href":"https:\/\/sarabio.jp\/lab\/index.php\/wp-json\/wp\/v2\/media?parent=108"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sarabio.jp\/lab\/index.php\/wp-json\/wp\/v2\/categories?post=108"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sarabio.jp\/lab\/index.php\/wp-json\/wp\/v2\/tags?post=108"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}