{"id":132,"date":"2018-08-24T11:28:00","date_gmt":"2018-08-24T02:28:00","guid":{"rendered":"https:\/\/sarabio.jp\/lab\/?p=132"},"modified":"2023-08-30T13:01:09","modified_gmt":"2023-08-30T04:01:09","slug":"%e3%80%90%e8%ab%96%e6%96%87%e6%8e%b2%e8%bc%89%e3%80%91%e3%83%a1%e3%83%87%e3%82%a3%e3%82%ab%e3%83%ab-%e3%82%b5%e3%82%a4%e3%82%a8%e3%83%b3%e3%82%b9-%e3%83%80%e3%82%a4%e3%82%b8%e3%82%a7%e3%82%b9%e3%83%88","status":"publish","type":"post","link":"https:\/\/sarabio.jp\/lab\/index.php\/achievement\/paper\/132\/","title":{"rendered":"\u3010\u8ad6\u6587\u63b2\u8f09\u3011\u30e1\u30c7\u30a3\u30ab\u30eb \u30b5\u30a4\u30a8\u30f3\u30b9 \u30c0\u30a4\u30b8\u30a7\u30b9\u30c8\uff08Medical Science Digest\uff09"},"content":{"rendered":"\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full\"><img width=\"900\" height=\"400\" src=\"https:\/\/sarabio.jp\/lab\/wp-content\/uploads\/2023\/08\/msd2018082401.jpg\" alt=\"\" class=\"wp-image-133\"\/><\/figure><\/div>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u81e8\u5e8a\u533b\u5b66\u306e\u5c02\u9580\u8a8c\u300c\u30e1\u30c7\u30a3\u30ab\u30eb\u30fb\u30b5\u30a4\u30a8\u30f3\u30b9\u30fb\u30c0\u30a4\u30b8\u30a7\u30b9\u30c8\uff08Medical Science Digest\uff09\u300d\u306e\u7279\u96c6\u300c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u57fa\u790e\u3068\u81e8\u5e8a\u300d\u306b\u3001\u6e29\u6cc9\u85fb\u985e\u7814\u7a76\u6240\u306e\u8ad6\u6587\u300e\u6e29\u6cc9\u5584\u7389\u83cc\u3068\u304a\u3093\u3076\u6cd5\u300f\u304c\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002 <\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2>\u300c\u30e1\u30c7\u30a3\u30ab\u30eb\u30fb\u30b5\u30a4\u30a8\u30f3\u30b9\u30fb\u30c0\u30a4\u30b8\u30a7\u30b9\u30c8\u300d\u306b\u3064\u3044\u3066<\/h2>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>\u300c\u30e1\u30c7\u30a3\u30ab\u30eb\u30fb\u30b5\u30a4\u30a8\u30f3\u30b9\u30fb\u30c0\u30a4\u30b8\u30a7\u30b9\u30c8\u300d<\/strong>\u306f\u3001\u6771\u4eac\u5927\u5b66\u3001\u4eac\u90fd\u5927\u5b66\u3001\u6176\u5fdc\u5927\u5b66\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u6700\u5148\u7aef\u306e\u533b\u5e2b\u30fb\u7814\u7a76\u8005\u3089\u304c\u7de8\u96c6\u3057\u3066\u3044\u308b<strong>\u81e8\u5e8a\u533b\u5b66\u306e\u5c02\u9580\u8a8c<\/strong>\u3067\u3059\u3002<br> 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\u5316\u7ca7\u54c1\u76ae\u819a\u79d1\u5b66\u306e\u56fd\u969b\u5b66\u4f1a\uff08\u30a2\u30e1\u30ea\u30ab 2015\u5e74\uff09\u3067\u306e\u8b1b\u6f14\u7b49\u304c\u8a55\u4fa1\u3055\u308c\u3001\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<br> \u6e29\u6cc9\u85fb\u300cRG92\u300d\u3084\u300c\u6e29\u6cc9\u9175\u6bcd\u300d\u306b\u3064\u3044\u3066\u57f7\u7b46\u3057\u305f\u8ad6\u6587\u306f\u3001\u3053\u308c\u307e\u3067\u306b\u3082\u69d8\u3005\u306a\u5c02\u9580\u8a8c\u306b\u63b2\u8f09\u3055\u308c\u6ce8\u76ee\u3055\u308c\u3066\u304a\u308a\u307e\u3059\u304c\u3001\u4eca\u56de\u306e\u300c\u30e1\u30c7\u30a3\u30ab\u30eb\u30fb\u30b5\u30a4\u30a8\u30f3\u30b9\u30fb\u30c0\u30a4\u30b8\u30a7\u30b9\u30c8\u300d\u306b\u63b2\u8f09\u3055\u308c\u305f\u8ad6\u6587\u306f\u3001\u30b3\u30f3\u30d1\u30af\u30c8\u306b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3078\u306e\u52b9\u679c\u3092\u96c6\u7d04\u3057\u300e\u6e29\u6cc9\u5584\u7389\u83cc\u3068\u304a\u3093\u3076\u6cd5\u300f\u3068\u3044\u3046\u5185\u5bb9\u306b\u307e\u3068\u3081\u307e\u3057\u305f\u3002 \u672c\u8ad6\u6587\u3092\u7dcf\u62ec\u7684\u306b\u307e\u3068\u3081\u305f\u3082\u306e\u304c\u300c\u76ae\u819a\u306e\u5b89\u5168\u6027\u30fb\u6709\u7528\u6027\u8a55\u4fa1\u6cd5\u300d\u306b\u63b2\u8f09\u3055\u308c\u3066\u304a\u308a\u307e\u3059\u3002  <\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3>\u7de8\u96c6\u9867\u554f\u306e\u672c\u5eb6 \u4f51 \u7279\u5225\u6559\u6388\uff08\u4eac\u90fd\u5927\u5b66\uff09\u304c\u30ce\u30fc\u30d9\u30eb\u751f\u7406\u5b66\u30fb\u533b\u5b66\u8cde\u3092\u53d7\u8cde<\/h3>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>2018\u5e7410\u6708\u3001\u300c\u30e1\u30c7\u30a3\u30ab\u30eb\u30fb\u30b5\u30a4\u30a8\u30f3\u30b9\u30fb\u30c0\u30a4\u30b8\u30a7\u30b9\u30c8\u300d \u306e\u7de8\u96c6\u9867\u554f\u3067\u3042\u308b <strong>\u672c\u5eb6\u4f51\uff08\u307b\u3093\u3058\u3087 \u305f\u3059\u304f\uff09 \u7279\u5225\u6559\u6388\uff08\u4eac\u90fd\u5927\u5b66\uff09\u304c\u3001\u30ce\u30fc\u30d9\u30eb\u751f\u7406\u5b66\u30fb\u533b\u5b66\u8cde\u3092\u53d7\u8cde<\/strong>\u3055\u308c\u307e\u3057\u305f\u3002 \u4eca\u56de\u306e\u8ad6\u6587\u306f\u3001\u672c\u5eb6\u5148\u751f\u3088\u308a\u57f7\u7b46\u4f9d\u983c\u3092\u9802\u6234\u3057\u3001\u63b2\u8f09\u3055\u308c\u305f\u3070\u304b\u308a\u3067\u9a5a\u304d\u3068\u611f\u52d5\u306e\u30cb\u30e5\u30fc\u30b9\u3067\u3057\u305f\u3002<br>\u65e5\u672c\u4eba\u306e\u30ce\u30fc\u30d9\u30eb\u8cde\u53d7\u8cde\u306f\u30012\u5e74\u3076\u308a\u306726\u4eba\u76ee\u306b\u306a\u308a\u307e\u3059\u3002\u518d\u751f\u533b\u7642\u5206\u91ce\u3092\u5207\u308a\u62d3\u3044\u305f\u5c71\u4e2d \u4f38\u5f25 \u6559\u6388\u306e\u300ciPS\u7d30\u80de\u300d\u3001\u764c\u3084\u52a0\u9f62\u306b\u4f34\u3046\u65b0\u305f\u306a\u5206\u91ce\u3092\u5207\u308a\u62d3\u3044\u305f\u5927\u9685 \u826f\u5178 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aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2> \u8ad6\u6587\u30bf\u30a4\u30c8\u30eb \u300c\u6e29\u6cc9\u5584\u7389\u83cc\u3068\u304a\u3093\u3076\u6cd5\u300d\u63b2\u8f09\u5185\u5bb9<\/h2>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3> \u306f\u3058\u3081\u306b<\/h3>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f\u3001<span class=\"f_red\">\u30a8\u30cd\u30eb\u30ae\u30fc\uff08ATP\uff09\u306e\u5408\u6210\u3084\u6d3b\u6027\u9178\u7d20\uff08ROS\uff09\u306e\u7523\u751f<\/span>\u3092\u62c5\u3046\u91cd\u8981\u306a\u7d30\u80de\u5c0f\u5668\u5b98\u3067\u3042\u308b\u3002\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6a5f\u80fd\u4e0d\u5168\u306f\u3001\u69d8\u3005\u306a\u708e\u75c7\u6027\u3001\u81ea\u5df1\u514d\u75ab\u6027\u304a\u3088\u3073\u52a0\u9f62\u6027\u75be\u60a3\u306b\u5bc6\u63a5\u306b\u95a2\u4e0e\u3057\u3001\u305d\u306e\u52d5\u7684\u5f62\u614b\u5236\u5fa1\u306f\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u3002<br> 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class=\"f_red\">\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e<\/span>\u306a\u3069\u306e\u708e\u75c7\u6027\u75be\u60a3\u306e\u6539\u5584\u3092\u3082\u305f\u3089\u3059\u304c\u3001\u305d\u306e\u4f5c\u7528\u6a5f\u5e8f\u306b\u3064\u3044\u3066\u306f\u8b0e\u304c\u591a\u3044\u3002<br> \u30a4\u30bf\u30ea\u30a2\u3067\u306f\u30d5\u30a1\u30f3\u30b4\uff08\u6e29\u6cc9\u6ce5\uff09\u6cbb\u7642\u304c\u516c\u7684\u4fdd\u967a\u306b\u9069\u5fdc\u3055\u308c\u3066\u304a\u308a\u3001\u305d\u306e\u52b9\u679c\u306f\u5fae\u7d30\u85fb\u985e\u306b\u8d77\u56e0\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3002\u79c1\u305f\u3061\u306f\u5730\u57df\u8cc7\u6e90\u3067\u3042\u308b<strong>\u201c\u5225\u5e9c\u6e29\u6cc9\u201d<\/strong>\u304b\u3089\u7f8e\u5bb9\u3068\u5065\u5eb7\u306b\u6709\u7528\u306a\u3044\u304f\u3064\u304b\u306e\u5fae\u751f\u7269<strong class=\"f_red\">\u300c\u6e29\u6cc9\u5584\u7389\u83cc\u300d<\/strong>\u3092\u767a\u898b\u3057\u305f\u3002\u30d2\u30c8\u521d\u4ee3\u57f9\u990a\u7d30\u80de\u3092\u7528\u3044\u3066\u65b0\u305f\u306b\u898b\u51fa\u3057\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5f62\u614b\u3068\u6a5f\u80fd\u306b\u95a2\u3059\u308b\u77e5\u898b\u3068\u3068\u3082\u306b\u3001<strong class=\"f_red\">\u6e29\u6cc9\u5584\u7389\u83cc(\u6e29\u6cc9\u85fbRG92\u3001\u6e29\u6cc9\u9175\u6bcdM-1)\u306b\u3088\u308b\u708e\u75c7\u6027\u75be\u60a3\u306e\u6539\u5584<\/strong>\u306b\u5411\u3051\u305f\u53d6\u308a\u7d44\u307f\u3092\u7d39\u4ecb\u3059\u308b\u3002  <\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3>\u30d2\u30c8\u521d\u4ee3\u57f9\u990a\u7d30\u80de\u306b\u304a\u3051\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30c0\u30a4\u30ca\u30df\u30af\u30b9<\/h3>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u5404\u7a2e\u30d2\u30c8\u521d\u4ee3\u57f9\u990a\u7d30\u80de\u3092\u7528\u3044\u3066\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5f62\u614b\u3092\u89b3\u5bdf\u3057\u305f\u3068\u3053\u308d\u3001\u7dda\u7dad\u578b\u3001\u65ad\u7247\u578b\u306b\u52a0\u3048\u3066\u5927\u304d\u306a\u584a\u306e\u3088\u3046\u306a\u5f62\u614b\uff08\u4ee5\u4e0b\u3001\u4e38\u578b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\uff09\u304c\u5171\u5b58\u3057\u3066\u3044\u305f\u3002\u30e9\u30a4\u30d6\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306b\u3088\u308a\u4e38\u578b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f\u7dda\u7dad\u578b\u304c\u6298\u308a\u305f\u305f\u307e\u308c\u305f\u5f62\u614b\u3067\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u305f\u3002<br> \u4e38\u578b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f\u7dda\u7dad\u578b\u3068\u540c\u7b49\u306e\u819c\u96fb\u4f4d\u3092\u7dad\u6301\u3059\u308b\u304c\u3001<span class=\"f_red\">\u7dda\u7dad\u578b\u3068\u6bd4\u3079\u3066ATP\u7523\u751f\u91cf\u306e\u6e1b\u5c11\u3001ROS\u306e\u5897\u52a0<\/span>\u304c\u8a8d\u3081\u3089\u308c\u305f\u3002\u30d2\u30c8\u6bdb\u4e73\u982d\uff08DP\uff09\u7d30\u80de\u3067\u306f\u4e38\u578b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f<span class=\"f_red\">\u6bdb\u5468\u671f\u306e\u4f11\u6b62\u671f<\/span>\u3067\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u308b\u3068\u601d\u308f\u308c\u308b\u3002 <\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3>\u95a2\u7bc0\u708e\u3068\u6e29\u6cc9\u5584\u7389\u83cc<\/h3>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306f\u3001\u2460\u6ed1\u819c\u306e\u708e\u75c7\u3001\u2461\u30d1\u30f3\u30cc\u30b9\u5f62\u6210\uff08\u6ed1\u819c\u7d30\u80de\u306e\u7570\u5e38\u5897\u6b96\uff09\u3001\u2462\u8edf\u9aa8\u306e\u5206\u89e3\u3068\u3044\u30463\u6bb5\u968e\u3092\u7d4c\u3066\u95a2\u7bc0\u306e\u7834\u58ca\u3084\u6a5f\u80fd\u7570\u5e38\u3092\u5f15\u304d\u8d77\u3053\u3059\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3067\u3042\u308b\u3002<br>\u95a2\u7bc0\u708e\u306e\u767a\u751f\u3084\u9032\u884c\u306b\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304b\u3089\u306e\u904e\u5270\u306aROS\u306e\u653e\u51fa\u304c\u5bc6\u63a5\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3002\u95a2\u7bc0\u708e\u30e2\u30c7\u30eb\u3068\u3057\u3066\u3001\u30d2\u30c8\u6ed1\u819c\u7dda\u7dad\u82bd\u7d30\u80de\u306b\u708e\u75c7\u523a\u6fc0\u3092\u4e0e\u3048\u308b\u3068\u7dda\u7dad\u578b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6e1b\u5c11\u3068\u3068\u3082\u306bATP\u7523\u751f\u306e\u6e1b\u5c11\u3001ROS\u306e\u5897\u52a0\u304c\u8a8d\u3081\u3089\u308c\u305f\u3002\u3064\u307e\u308a\u3001\u95a2\u7bc0\u708e\u306e\u9032\u884c\u306b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304c\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u305f\u3002<br>\u6e29\u6cc9\u85fbRG92\u306f\u3053\u306e\u708e\u75c7\u523a\u6fc0\u306b\u3088\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5f62\u614b\u3068\u6a5f\u80fd\u306e\u5909\u8abf\u3092\u6291\u5236\u3059\u308b\uff08\u56f31\uff09\u3002\u5225\u9014\u3001RG92\u306f\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u304c\u9032\u884c\u3059\u308b3\u3064\u306e\u904e\u7a0b\u3092\u6291\u5236\u3059\u308b\u3002<br>\u3053\u306e\u3053\u3068\u304b\u3089\u3001RG92\u306f\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u9032\u884c\u3092\u9632\u3050\u306a\u3069\u3001\u708e\u75c7\u6027\u95a2\u7bc0\u708e\u306e\u65b0\u3057\u3044\u6cbb\u7642\u65b9\u6cd5\u306e\u767a\u5c55\u306b\u7e4b\u304c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u308b\u3002<\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"has-text-align-center\"><strong>\u56f3\uff5c\u6e29\u6cc9\u5584\u7389\u83cc\u3068\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2<\/strong><\/h4>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full\"><img width=\"619\" height=\"644\" src=\"https:\/\/sarabio.jp\/lab\/wp-content\/uploads\/2023\/08\/msd2018082402.jpg\" alt=\"\" class=\"wp-image-134\"\/><\/figure><\/div>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4><strong>A. \u6a5f\u80fd\u76f8\u95a2\u56f3<\/strong><\/h4>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u6e29\u6cc9\u85fbRG92\u306f\u6d3b\u6027\u9178\u7d20\u306e\u7523\u751f\u3092\u963b\u5bb3\u3057\u3001\u708e\u75c7\u30fb\u9178\u5316\u30fb\u7cd6\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u708e\u75c7\u56e0\u5b50\u306e\u5897\u52a0\u3084\u7d30\u80de\u306e\u969c\u5bb3\u30fb\u8001\u5316\u3092\u6291\u5236\u3059\u308b\u3002\u3055\u3089\u306b\u9577\u5bff\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u5897\u5f37\u3057\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6a5f\u80fd\u3092\u9ad8\u3081\u308b\u3053\u3068\u3067\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u4f5c\u7528\u3092\u767a\u63ee\u3059\u308b\u3002\u6e29\u6cc9\u9175\u6bcdM-1\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u7523\u751f\u52b9\u7387\u3084\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u6a5f\u80fd\u3092\u9ad8\u3081\u308b\u3068\u3068\u3082\u306b\u3001\u4e00\u6b21\u7e4a\u6bdb\u3092\u4ecb\u3057\u305f\u6210\u9577\u56e0\u5b50\u306e\u5897\u5f37\u4f5c\u7528\u306b\u3088\u308a\u7d30\u80de\u5897\u6b96\u3084\u518d\u751f\u3092\u4fc3\u3059\u3002<\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full\"><img width=\"619\" height=\"175\" src=\"https:\/\/sarabio.jp\/lab\/wp-content\/uploads\/2023\/08\/msd2018082403.jpg\" alt=\"\" class=\"wp-image-135\"\/><\/figure><\/div>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4><strong>B. \u304a\u3093\u3076 (OMB, Onsen-based Mitochondrial Boosting\uff09\u6cd5<\/strong> <\/h4>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u30b9\u30c8\u30ec\u30b9\u3092\u53d7\u3051\u308b\u3068\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f\u4e38\u578b\u306b\u30b7\u30d5\u30c8\u3057\u3001ATP\u7523\u751f\u306e\u8131\u5171\u5f79\u3092\u3082\u305f\u3089\u3059(\u4e0a)\u3002\u6e29\u6cc9\u85fbRG92\u306f\u4e38\u578b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3068\u7dda\u7dad\u578b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u6574\u3048\u3001ATP\u7523\u751f\u306e\u6b63\u5e38\u5316\u3068\u904e\u5270\u306aROS\u306e\u767a\u751f\u3092\u6291\u5236\u3059\u308b\u3002\u6e29\u6cc9\u9175\u6bcdM-1\u306f\u3055\u3089\u306b\u7dda\u7dad\u578b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u5897\u3084\u3059\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u7387\u7684\u306aATP\u7523\u751f\u3092\u4fc3\u3059(\u4e0b)\u3002\u5b9f\u969b\u306f\u53cc\u65b9\u306e\u30bf\u30a4\u30d7\u3067ATP\u3082ROS\u3082\u7523\u751f\u3059\u308b\u304c\u3053\u3053\u3067\u306f\u7c21\u7d20\u5316\u3057\u3066\u63cf\u5199\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3>\u76ae\u819a\u75be\u60a3\u3068\u6e29\u6cc9\u5584\u7389\u83cc<\/h3>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u5186\u5f62\u8131\u6bdb\u75c7\u306a\u3069\u306e\u5404\u7a2e\u8131\u6bdb\u75c7\u306b\u3082\u708e\u75c7\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3002\u79c1\u305f\u3061\u306fDP\u7d30\u80de\u306b\u304a\u3044\u3066\u3001\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff08AGEs\uff09\u304cROS\u7523\u751f\u3068NF-kB\u7d4c\u8def\u3092\u4ecb\u3057\u305f\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u767a\u73fe\u3092\u4ea2\u9032\u3059\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u305f\u3002ROS\u3078\u306e\u5f71\u97ff\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u95a2\u4e0e\u3092\u3046\u304b\u304c\u308f\u305b\u308b\u3002<br>\u307e\u305f\u3001DP\u7d30\u80de\u306f\u6bdb\u5305\u5f62\u6210\u3084\u6bdb\u5468\u671f\u306e\u5236\u5fa1\u306b\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u7d30\u80de\u904a\u8d70\u6642\u306b\u306f\u7dda\u7dad\u578b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304c\u652f\u914d\u3059\u308b\u3002\u3064\u307e\u308a\u3001\u6bdb\u9aea\u306e\u5236\u5fa1\u306b\u304a\u3044\u3066\u3001DP\u7d30\u80de\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5f79\u5272\u306f\u91cd\u8981\u3067\u3042\u308b\u3002<br>RG92\u306fDP\u7d30\u80de\u306b\u304a\u3044\u3066\u3001AGEs\u306b\u3088\u308b\u904e\u5270\u306aROS\u7523\u751f\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067\u708e\u75c7\u3092\u6291\u5236\u3057\u3001\u708e\u75c7\u523a\u6fc0\u3067\u5d29\u58ca\u3059\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5f62\u614b\u30d0\u30e9\u30f3\u30b9\u3092\u6b63\u5e38\u5316\u3059\u308b\u3002<br>\u3055\u3089\u306b\u6e29\u6cc9\u9175\u6bcdM-1\u306f\u3088\u308a\u52b9\u7387\u7684\u306bATP\u3092\u7523\u751f\u3059\u308b\u7dda\u7dad\u578b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u5897\u3084\u3057\u3001\u7d30\u80de\u5897\u6b96\u3084\u904a\u8d70\u80fd\u306a\u3069\u306e\u7d30\u80de\u6a5f\u80fd\u3092\u9ad8\u3081\u308b\u3002\u3053\u308c\u3089\u306f\u6e29\u6cc9\u5584\u7389\u83cc\u306e\u4f5c\u7528\u304c\u8131\u6bdb\u75c7\u306e\u6539\u5584\u306b\u7e4b\u304c\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002<br>\u30d2\u30c8\u771f\u76ae\u7dda\u7dad\u82bd\u7d30\u80de\u306b\u304a\u3044\u3066\u3082\u540c\u69d8\u306b\u7dda\u7dad\u578b\u3068\u4e38\u578b\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304c\u89b3\u5bdf\u3055\u308c\u305f\u3002\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u3001\u4e7e\u766c\u306a\u3069\u306e\u76ae\u819a\u75be\u60a3\u306b\u304a\u3044\u3066\u3082\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5909\u8abf\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3068\u601d\u308f\u308c\u308b\u3002\u6e29\u6cc9\u85fbRG92\u304c\u63bb\u75d2\u306b\u95a2\u308f\u308b\u4e00\u9023\u306e\u56e0\u5b50\u3092\u6291\u3048\u308b\u3053\u3068\u306f\u6ce8\u76ee\u306b\u5024\u3059\u308b\u3002\u76ae\u819a\u708e\u306e\u518d\u71c3\u3092\u9632\u3050\u305f\u3081\u306e\u300cProactive\u7642\u6cd5\u300d\u306e\u3088\u3046\u306a\u4f4d\u7f6e\u3065\u3051\u3067\u306e\u4f7f\u7528\u3092\u63d0\u6848\u3057\u305f\u3044\u3002<\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3>\u304a\u308f\u308a\u306b\u3000\uff5e\u304a\u3093\u3076\uff08OMB, Onsen-based Mitochondrial Boosting\uff09\u6cd5\uff5e<\/h3>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u5225\u5e9c\u6e29\u6cc9\u3067\u767a\u898b\u3057\u305f\u6e29\u6cc9\u5584\u7389\u83cc\u306f\u3001\u5404\u708e\u75c7\u6027\u75be\u60a3\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u3001\u75c7\u72b6\u306e\u6539\u5584\u304c\u671f\u5f85\u3055\u308c\u308b\u4f5c\u7528\u3092\u793a\u3057\u305f<span class=\"f_70\">\uff08\u56f31A\uff09<\/span>\u3002<span class=\"f_red\">\u6e29\u6cc9\u85fbRG92\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5f62\u614b\u30d0\u30e9\u30f3\u30b9\u3092\u6574\u3048\u3001ATP\u7523\u751f\u306e\u6b63\u5e38\u5316\u3068\u904e\u5270\u306aROS\u767a\u751f\u3092\u6291\u5236<\/span>\u3059\u308b\u3002<span 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